Plasma and tumor DNA sequencing in oligometastatic breast cancer
Targeted sequencing of DNA extracted from plasma, tumors, and buffy coat of blood was performed to determine whether plasma DNA reflects the genomes of multiple tumors in patients with oligometastatic breast cancer.
Organism: Homo sapiens
Data Type: DNA sequencing of select genes
Accession: PRJNA604239
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Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer
Whole-transcriptome sequencing of ER+ breast cancer cell lines (MCF-7 and T47D) treated with the anti-estrogen fulvestrant +/- fibroblast growth factor (FGF2).
Organism: Homo sapiens
Data Type: RNA sequencing
Accession: PRJNA389319
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Genome-wide copy number profiling of MCF-7 and fulvestrant-resistant MCF-7/FR cells by SNP microarray
Genome-wide SNP arrays were used to profile MCF-7 cells and fulvestrant-resistant derivatives (MCF-7/FR). Gene copy number was inferred from SNP array data.
Organism: Homo sapiens
Data Type: Genome variation profiling by SNP array
Accession: GSE121631
Platform:
GPL6801
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Fulvestrant withdrawal from fulvestrant-resistant MCF-7/FR cells
Fulvestant-resistant MCF-7 cells were treated with fulvestrant withdrawal over a time course. MCF-7 cells were treated +/- fulvestrant as controls. Transcriptome-wide gene expression was profiled using Illumina BeadChip arrays.
Organism: Homo sapiens
Data Type: Expression profiling by array
Accession: GSE121379
Platform:
GPL10558
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Cytokine sensitivity screening highlights BMP4 signaling as a therapeutic opportunity in ER+ breast cancer
Whole-transcriptome sequencing of ER+ breast cancer cell lines (MCF-7 and T47D) treated +/- bone morphogenetic protein 4 (BMP4).
Organism: Homo sapiens
Data Type: Whole-transcriptome RNA sequencing
Accession: PRJNA474748
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Breast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program
MCF-7 and HCC-1428 cells, and long-term estrogen-deprived (LTED) derivatives, were analyzed using Affymetrix arrays to profile transcriptome-wide gene expression.
Organism: Homo sapiens
Data Type: Expression profiling by array
Accession: GSE22533
Platform:
GPL570
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Estrogen-independent genomic ER binding analysis
Long-term estrogen-deprived (LTED) derivatives of MCF-7 and HCC-1428 cells (MCF-7/LTED and HCC-1428/LTED) were analyzed by ChIP-seq for estrogen receptor a to identify ER-DNA binding events that occur in the absence of estrogens.
Organism: Homo sapiens
Data Type: Genome binding/occupancy profiling by high throughput sequencing
Accession: GSE27300
Platform:
GPL9115
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Hyperactivation of PI3K promotes escape from hormone dependence in estrogen receptor-positive breast cancer
MCF-7, ZR75-1, HCC-1428, and MDA-MB-361 cells and their long-term estrogen-deprived (LTED) derivatives were analyzed using Affymetrix arrays to profile transcriptome-wide gene expression.
Organism: Homo sapiens
Data Type: Expression profiling by array
Accession: GSE19639
Platform:
GPL570
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