Welcome to the Miller Lab at the Medical College of Wisconsin Cancer Center. Our lab is focused on understanding the causes of drug resistance in breast cancer and the discovery of new treatment strategies.
Oxidative Phosphorylation is a Metabolic Vulnerability of Endocrine Therapy-Tolerant Persister Cells in ER+ Breast Cancer.
Steven Tau, Mary D Chamberlin, Huijuan Yang, Jonathan D Marotti, Patricia C Muskus, Alyssa M Roberts, Melissa M Carmichael, Lauren Cressey, Christo Philip C Dragnev, Eugene Demidenko, Riley A Hampsch, Shannon M Soucy, Fred W Kolling, Kimberley S Samkoe, James V Alvarez, Arminja N Kettenbach, Todd W Miller.
Cancer Res. 2025 Jan 9. doi: 10.1158/0008-5472.CAN-24-1204. Online ahead of print.
Extensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple-negative breast cancer.
Youdinghuan Chen, Lucas A Salas, Jonathan D Marotti, Nicole P Jenkins, Chao Cheng, Todd W Miller, Arminja N Kettenbach, Brock C Christensen.
Int J Cancer. 2025 Mar 15;156(6):1191-1202. doi: 10.1002/ijc.35274. Epub 2024 Dec 5.
Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer.
Meisam Bagheri, Gadisti Aisha Mohamed, Mohammed Ashick Mohamed Saleem, Nevena B Ognjenovic, Hanxu Lu, Fred W Kolling, Owen M Wilkins, Subhadeep Das, Ian S LaCroix, Shivashankar H Nagaraj, Kristen E Muller, Scott A Gerber, Todd W Miller, Diwakar R Pattabiraman.
Cell Rep Med. 2024 Apr 16;5(4):101504. doi: 10.1016/j.xcrm.2024.101504. Epub 2024 Apr 8.