Presurgical treatment with letrozole in patients with early-stage breast cancer
Presurgical treatment with letrozole in patients with early-stage breast cancer Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer.
NCT02010021
This study evaluated whether mTORC1 inhibition of ER+/HER2- primary breast tumors ex vivo activates feedback signaling to IRS-1/PI3K/AKT, and whether presurgical treatment with an aromatase inhibitor abrogates such feedback.
Reference manuscript
Wei Yang, Gary N Schwartz, Jonathan D Marotti, Vivian Chen, Nicole A Traphagen, Jiang Gui, Todd W Miller.
Oncotarget. 2018 Jan 15;9(10):8810-8822. doi: 10.18632/oncotarget.24256. eCollection 2018 Feb 6.